Early research suggests that a popular non-psychoactive compound is derived from Marijuana can help prevent or treat Covid-19 justifies further investigation in rigorous clinical trials, the researchers say.
Several recent laboratory studies on cannabidiol, or CBD, have shown promising results, which have attracted media attention.
Many other potential Covid-19 treatments that have shown promise in test tubes, from hydroxychloroquine to various drugs used to treat cancer and other diseases, have ultimately shown no benefit to Covid-19 patients once studied in clinical trials. .
Marsha Rosner of the University of Chicago, led a team that found that CBD was apparently helping to EARS-CoV-2 in infected cells in laboratory experiments. “Our findings do not say that it will work in patients. Our findings make a strong case for conducting a clinical trial,” he said.
The use of small doses of highly purified CBD Rosner and colleagues found that CBD does not prevent the coronavirus from infecting cells in test tubes.
Rather, it occurred shortly after the virus invaded cells, preventing it from making copies of itself, in part through effects on the inflammatory protein interferon. They found similar effects in infected mice, according to a report published in Science Advances.
When looking at a group of adults with severe epilepsy, the researchers found that those who took the approved drug containing CBD had lower rates of Covid-19. But a retrospective look at a small number of patients does not provide conclusive information. Only randomized clinical trials can do that, Rosner said.
“I know my message is not something people want to hear,” he said.
His team found that small doses of tetrahidrocannabinol (THC) -the ingredient in weed causes psychoactive effects cannabidiolic acid (CBDA), cannabidivarien (CBDV), cannabicromina (CBC) y cannabigerol (CBG) did not keep the virus out of cells or prevent their replication.
“Not only did the THC not work, but the combination with the CBD prevented the CBD from working,” Rosner said.
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